Kim, Hong-Soo; Song, Choon-Ho

This study was undertaken to determine whether Scutellaria baicalensis Georgi (SbG) extract exerts the protective effect against -induced alterations in membrane transport function in rabbit renal cortical slices. The slices were treated with 0.1 mM for 60 min at . caused an inhibition in PAH uptake by renal cortical slices. Such an effect was accompanied by depressed -ATPase activity and ATP depletion. SbG prevented -induced inhibition of PAH uptake in a dose-dependent manner at the concentration ranges of 0.01-0.1%. -induced inhibition of -ATPase activity and ATP depletion were significantly prevented by 0.05% SbG. These results suggest that SbG prevents -induced alterations in membrane transport function in rabbit renal cortical slices. Such protective effects of SbG may be attributed to inhibition of peroxidation of membrane lipid.

Scutellaria baicalensis Georgi; ; Membrane transport dysfunction; Rabbit renal cortical slice; PAH uptake; activ

This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.