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Article
Effects of Modified Sedang-Hwan added Hog Pancreas on the Experimental Diabetes of Rat induced by Streptozotocin
Lee, Chang-Geun; Soh, Kyeong-Sun; Jeong, Chan-Gil
Abstract
Objectives We performed this study in order to investigate the effects of Sedang-Hwan(世糖丸) and modified Sedang-Hwan(世糖丸變方)on the diabetes mellitus. Methods We injected a vein with 65mg/kg of streptozotocin(STZ) on the rats. And then administered Sedang-Hwan(Sample 1 group); 18.7mg/kg/day, modified Sedang-Hwan; 16.5mg/kg/day(Sample 2 group) to Sample groups and observed the body weight, glucose and insulin levels. Results 1. The Sample 1, 2 groups showed a high suppressive effect of body weight loss compared to Control group. 2. The Sample 1, 2 groups’ glucose level showed a effective in lowering level compared to Control group. 3. The sample 1, 2 groups showed a higher insulin level than Control group. Conclusions Conclusively, modified Sedang-hwan was recognized to have decrease effect of serum glucose of the diabetic rats induced by streptozotocin. It is also required to study on the further detailed mechanism of decrease effect of serum glucose by modified Sedang-hwan.
Keywords
Sedang-Hwan; modified Sedang-Hwan; Streptozotocin; Rats; Diabetes Mellitus
Open Access
This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright © 2014 Journal of Pharmacopuncture. All rights reserved.