Original
Beneficial Effects of Capparis Spinosa Honey on the Immune Response of Rats Infected with Toxoplasma Gundii
Ahmed Gaffer Hegazi, Fayez Mohammed Al Guthami, Ahmed Faiz Al Gethami, Hassan Ali El Fadaly,
Keywords: Capparis spinosa honey, cytokines, Saudi Arabia, Toxoplasma gundii
DOI: http://dx.doi.org/10.3831/KPI.2017.20.015
Objectives:
The Toxoplasma gondii (T. gondii) is an intracellular opportunistic protozoan parasite that infects approximately one-third of the human population worldwide. Honey has long been used for treatment of many diseases in folk medicine. Honey has exhibited significant anthelmintic, nematicidal and anti-protozoal activities.
This study was conducted to investigate the immunological patterns in rats infected with T. gondii who were treated orally with supplemented 15% Capparis spinosa honey (Saudi Arabia) for a period of 28 days.
Methods:
Immunoglobulin M, immunoglobulin G, and cytokines were detected by using enzyme-linked immunosorbent assays (ELISAs). In addition, the mortality and the morbidity rates were assessed.
Results:
Oral administration of Capparis spinosa honey as a natural food additive was experimentally shown to increase the antibody titer; furthermore, compared with the rats in the control group, the levels of the sera cytokines (IFN-γ, IL-1 and IL-6) were consistently higher at day 7 post-infection in the infected rats treated with oral supplements of Capparis spinosa honey.
Conclusion:
Orally administered supplements of Capparis spinosa honey increased both the antibody titer and the cytokines (IFN-γ, IL-1 and IL-6) levels in rats infected with T. gondii.