Report on the changes of LD50 of Bee venom Herbal Acupuncture

Jang, Seong-Bong; Choi, Young-Kwon; Kwon, Ki-Rok

Keywords: Bee Venom Herbal Acupuncture; LD50; manufacturing process; toxin; venom

DOI: http://dx.doi.org/10.3831/KPI.2005.8.1.041

Objectives : This experiment was conducted to reevaluate of Korean bee venom acupuncture as many changes have occurred over the years. Methods : ICR mice were used as the experiment animals and bee venom acupuncture was manufactured under the protocols of Korean Institute of herbal Acupuncture. Based on the previous reports, experiment was divided into pre and main sections. Results : 1. Presumed value is at 5.25mg/kg 2. Deaths of experiment animals occurred within 48 hours. 3. Reduced toxicity of the bee venom acupuncture is likely to be the results of more refined manufacturing process and production. Conclusion : Comparing with the values of the previous results, toxicity of the bee venom acupuncture showed significant changes and more accurate findings on value must be accomplished to lead further studies on the bee venom acupuncture