Beneficial Effect of Scutellaria baicalensis Georgi Extract on Mercury Chloride-Induced Membrane Transport Dysfunction in Rabbit Renal Cortical Slices

Kim, Hong-Soo; Song, Choon-Ho

Keywords: Scutellaria baicalensis Georgi; ; Membrane transport dysfunction; Rabbit renal cortical slice; PAH uptake; activ

DOI: http://dx.doi.org/10.3831/KPI.2001.4.2.049

This study was undertaken to determine whether Scutellaria baicalensis Georgi (SbG) extract exerts the protective effect against -induced alterations in membrane transport function in rabbit renal cortical slices. The slices were treated with 0.1 mM for 60 min at . caused an inhibition in PAH uptake by renal cortical slices. Such an effect was accompanied by depressed -ATPase activity and ATP depletion. SbG prevented -induced inhibition of PAH uptake in a dose-dependent manner at the concentration ranges of 0.01-0.1%. -induced inhibition of -ATPase activity and ATP depletion were significantly prevented by 0.05% SbG. These results suggest that SbG prevents -induced alterations in membrane transport function in rabbit renal cortical slices. Such protective effects of SbG may be attributed to inhibition of peroxidation of membrane lipid.